Reducing blood pressure and anxiety in mice

US researchers have identified brain cells (neurons) in mice that, when activated with light, can significantly reduce both blood pressure and anxiety.

Heart disease accounts for about one third of all deaths worldwide and chronic stress and anxiety are recognised as risk factors for both high blood pressure and cardiovascular disease, although the connection remains poorly understood.

A study at Georgia State University (GSU) now literally sheds light on the connection between mental and physical health using a technique called optogenetics, which can control of neuron activity using light (known as optogenetics).

Using light, the researchers activated the receptors (AT2R) in the neurons in a specific area of the brain called amygdala, that is associated with emotion regulation.

Optogenetic activation of these neurons in mice lowered both blood pressure and anxiety levels and in a parallel experiment these effects were also observed, using a drug that also targets AT2R.

Lead researcher Eric Krause, at Georgia State University said: “Our studies suggest that AT2R neurons in the amygdala may contribute to the improved mood and heart health benefits that come with mind-body practices.”

The research team is now investigating if the drug used in the study, delivered nasally, can improve mental and heart health in humans. The research was published in The Journal of Neuroscience.