This year’s Nobel Prize winners for Physiology or Medicine used animal models to develop their novel cancer therapy.
James P. Allison, of the University of Texas MD Anderson Cancer Center, USA, and Tasuku Honjo, of Kyoto University, Japan, discovered in mice a way of unleashing immune cells to attack tumours by turning off the safeguards in the immune system that prevent it from attacking human tissue.
In turn, new drugs can now be developed offering hope to patients with advanced and previously untreatable cancer. Immune checkpoint therapy is already used to treat people with the most serious form of skin cancer, melanoma.
Cancer kills millions of people each year and is one of humanity’s greatest health challenges. By stimulating the inherent ability of our immune system to attack tumour cells this year’s Nobel Laureates have established an entirely new principle for cancer therapy. Continue reading